Steve Buscemi has seen it all. He was hit by a car and a bus as a kid, was once stabbed in a bar fight, volunteered as a firefighter during 9/11, and somewhere along the way became one of the most accomplished film actors of his generation.

And then tragedy struck: In 2019, Buscemi lost his wife of over 30 years. In a rare interview, Hollywood's most beloved misfit opens up about anxiety, loss, and the hard work of getting through it all.