Finding an oasis of calm in Manhattan is a tall order, but the Moxy Hotel Chelsea, nestled in New York’s Flower District, is that rare treat. With nods to Art Deco and Italian Futurism, this 349-room hotel, which opened in February, ushers you into a Roman idyll that compliments the offerings of the nearby NoMad and Ace Hotels.

Occupying a new 35-story building designed by architects Stonehill Taylor, this Moxy—the third to open in New York City and the second Moxy developed by Lightstone—leans on its Italian heritage (the first Moxy was in Milan) and its neighborhood’s legacy as a botanical marketplace.