The journal Cell Death & Disease (Nature) has published an international study on COVID-19 coordinated by Professors Giuseppe Novelli (University of Tor Vergata – University of Nevada, USA) and Pier Paolo Pandolfi (University of Turin – University of Nevada, USA), in collaboration with the Bambino Gesù Hospital (Rome), Istituto Spallanzani (Rome), San Raffaele University (Rome) and several US (Harvard, Yale, Rockefeller, NIH, Mount Sinai, Boston University), Canadian (University of Toronto) and French (INSERM Paris, Hôpital Avicenne) institutions.

The international team identified a class of enzymes (E3-ubiquitin ligases) needed by the SARS-CoV-2 virus to leave infected cells and spread to all tissues in the body.