Well, figuring out where to travel in Italy is hard enough: From Venice and Milan in the north, Rome, Florence, and Tuscany in the center, and the Amalfi Coast and Sicily in the south, there are so many destinations to choose from.
You'll have to figure that out on your own—but we've done the legwork to find amazing vacation rentals in all of the cities and regions above, plus lesser-known towns in Le Marche and Puglia, once you've settled on a location.