The Chicago Cubs signed versatile infielder Nicky Lopez to a one-year contract on April 23, 2025 after releasing him earlier in the spring. The Cubbies initially offered a minor-league deal with an invite to Spring Training on February 7, 2025, but the 30-year-old utility man was one of the final roster cuts before the MLB Tokyo Series against the Los Angeles Dodgers.

During 2025 Spring Training with the Cubs, he played in nine games and hit .450 (9-for-20). The Team Italy 2023 World Baseball Classic spark plug (9-for-19, .474 BA, 2B, 3B, BB, SB, 2 R, 7 RBI) was an American League Gold Glove finalist last season while holding down second base for the Chicago White Sox (124 games, .241 BA).