Busio moved to Venezia in August 2021, with the club breaking its own transfer record to sign the midfielder from Sporting KC. However, the club would be relegated to Serie B after that season before finishing eighth in the second division last season.

Busio was in and out of the lineup last season, but did make 28 total appearances. However, the drop to Serie B, and his loss of form, led to him making just one U.S. men's national team appearance in 2022 after featuring eight times in 2021.