The muffaletta (also spelled muffuletta), like the po'-boy, was created in what I like to think of as my own (extended) backyard: the incomparable city of New Orleans.
Of Sicilian origin, muffuletta is actually the name of the Italian bread that holds the virtual charcuterie board of ingredients that make up this massive sandwich together. If you've never seen one, muffaletta bread is a large, round, somewhat flat, sesame seed-topped loaf, traditionally baked and wrapped in paper during religious holidays in Sicily.