Forget the old adage “all roads lead to Rome.” Sometimes, you just wanna get out of the Eternal City, with its blistering summers and maddening traffic jams. Luckily, Lazio and the surrounding regions of Tuscany and Umbria, contain a wealth of artistic and culinary treasures worthy of a day trip or long weekend.

From exploring the Renaissance villas and gardens of Tivoli—an essential stop on the Grand Tour—to visiting the wineries of Tuscany’s picturesque Val d’Orcia and living la dolce vita at a chic country estate, you’ll find plenty of inspiration in this guide to the five best day trips from Rome.