Cremona is located in the middle of the Po Valley on the Po River and can be reached from the other provinces of Lombardy, by car, by train, or by bike using the cycle paths along the Po River, which also connects Cremona to Piacenza, in Emilia Romagna.

Historically this city, for its location, has always been important both economically and politically. It was originally founded by the Celts and later in 218 BC, the Romans arrived and established their military outpost to control the area.