Virtually every major American city has its own Italian neighborhood. Some of the most well-known, such as Manhattan's Little Italy, Boston's North End, and Federal Hill in Providence, Rhode Island, lie on the East Coast.

San Francisco has North Beach, while farther inland, Chicago has University Village, per AFAR. Missouri, however, is special. It has not one but two distinct Italian neighborhoods in the two cities that bookend the state. To the east, St. Louis has The Hill, while on the west side, Kansas City has Columbus Park.